CHP and San Francisco Police officers are on scene blocking lanes of traffic for rescue personnel.
At least four occupants sustained injuries during the collision.
Firefighters are on the scene of a five car pileup on the I-280 near the U.S. 101 interchange.
California Highway Patrol (CHP) officers and firefighters are responding to a reported collision.
Incident reported at U.S. 101 & I-280.